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Our Publications


Qiu Y, O’Neill N, Maffei B, Zourray C, Almacellas-Barbanoj A, Carpenter JC, Jones SP, Leite M, Turner TJ, Moreira FC, Snowball A, Shekh-Ahmad T, Magloire V, Barral S, Kurian MA, Walker MC, Schorge S, Kullmann DM, Lignani G.

Science. 2022; 378(6619):523-532.

Carpenter C, Lignani G.

Epilepsy Currents. In press

Valassina N, Brusco S, Salamone A, Serra L, Luoni M, Giannelli S, Bido S, Massimino L, Ungaro F, Mazzara PG, D'Adamo P, Lignani G, Broccoli V, Colasante G.

Nat Commun. 2022 Jan 10;13(1):161.

Zourray C, Kurian MA, Barral S, Lignani G.

Front Mol Neurosci. 2022 Feb 16;15:839366.


Lubroth P, Colasante G, Lignani G.

In vivo Genome Editing Therapeutic Approaches for Neurological Disorders: Where Are We in the Translational Pipeline?

Front Neurosci. 2021 Feb 18;15:632522.

Rossignoli G, Krämer K, Lugarà E, Alrashidi H, Pope S, De La Fuente Barrigon C, Barwick K, Bisello G, Ng J, Counsell J, Lignani G, Heales SJR, Bertoldi M, Barral S, Kurian MA.

Aromatic l-amino acid decarboxylase deficiency: a patient-derived neuronal model for precision therapies.

Brain. 2021 Mar 17:awab123.

Carpenter JC, Männikkö R, Heffner C, Heneine J, Sampedro-Castañeda M, Lignani G, Schorge S.

Progressive myoclonus epilepsy KCNC1 variant causes a developmental dendritopathy

Epilepsia. 2021 May;62(5):1256-1267.

Magloire V, Lignani G.

DBS for refractory epilepsy: is closed-loop stimulation of the medial septum the way forward?

Brain​ 2021 Apr 12;144(3):702-705.

Ng J, Barral S, De La Fuente Barrigon C, Lignani G, Erdem FA, Wallings R, Privolizzi R, Rossignoli G, Alrashidi H, Heasman S, Meyer E, Ngoh A, Pope S, Karda R, Perocheau D, Baruteau J, Suff N, Antinao Diaz J, Schorge S, Vowles J, Marshall LR, Cowley SA, Sucic S, Freissmuth M, Counsell JR, Wade-Martins R, Heales SJR, Rahim AA, Bencze M, Waddington SN, Kurian MA.

Gene therapy restores dopamine transporter expression and ameliorates pathology in iPSC and mouse models of infantile parkinsonism.

Science Translational Medicine. 2021 May 19.

Carpenter JC, Lignani G.

Gene Editing and Modulation: the Holy Grail for the Genetic Epilepsies?

Neurotherapeutics. 2021 Jul 7.

Prestigio C, Ferrante D, Marte A, Romei A, Lignani G, Onofri F, Valente P, Benfenati F, Baldelli P.

REST/NRSF drives homeostatic plasticity of inhibitory synapses in a target-dependent fashion.

eLife. 2021 Dec 2;10:e69058.


Colasante G, Lignani G, Brusco S, Di Berardino C, Carpenter J, Giannelli S, Valassina N, Bido S, Ricci R, Castoldi V, Marenna S, Church T, Massimino L, Morabito G, Benfenati B, Schorge S, Leocani L, Kullmann DM, Broccoli V.

dCas9-based Scn1a gene activation restores inhibitory interneuron excitability and attenuates seizures in Dravet syndrome mice

Molecular Therapy. 2020 Jan 8; 28(1): 235–253.

Colasante G, Qiu Y, Massimino L, Di Berardino C, Cornford JH, Snowball A, Weston M, Jones SP, Giannelli S, Lieb A, Schorge S, Kullmann DM, Broccoli V, Lignani G.

In vivo CRISPRa decreases seizures and rescues cognitive deficits in a rodent model of epilepsy

Brain. 2020 Mar 1;143(3):891-905.

Lignani G, Baldelli P, Marra V.

Homeostatic Plasticity in Epilepsy.

Front Cell Neurosci. 2020 Jun 26;14:197.

Turner T, Zourray C, Schorge S, Lignani G

Recent advances in gene therapy for neurodevelopmental disorders with epilepsy.

J Neurochem. 2020 Sep 2.

Lugarà E, Kaushik R, Leite M, Chabrol E, Dityatev A, Lignani G, Walker MC.

LGI1 downregulation increases neuronal circuit excitability.

Epilepsia. 2020 Oct 26.


Lugara E, Lignani G, Benfenati F, Humeau Y.

Synapsin I controls synaptic maturation of cortical and thalamic long-term projections in the lateral amygdala.

Frontiers in Molecular Neuroscience. 1 May 2019.

Weston M, Kaserer T, Wu A, Mouravlev A, Carpenter JC, Snowball A, Knauss S, von Schimmelmann M, During MJ, Lignani G, Schorge S, Young D, Kullmann DM, Lieb A

Olanzapine: A potent agonist at the hM4D(Gi) DREADD amenable to clinical translation of chemogenetics.

Sci Adv. 2019 Apr 17;5(4):eaaw1567.

Rocchi A, Moretti D, Lignani G, Colombo E, Scholz-Starke J, Baldelli P, Tkatch T, Benfenati F.

Neurite-Enriched MicroRNA-218 Stimulates Translation of the GluA2 Subunit and Increases Excitatory Synaptic Strength.

Mol Neurobiol. 2019 Jan 23.

Salpietro V, Dixon CL, Guo H, Bello OD <i>et al</i>.

AMPA receptor GluA2 subunit defects are a cause of neurodevelopmental disorders.

Nat Commun. 2019 Jul 12;10(1):3094.


Wykes RC, Lignani G.

Gene therapy and editing: Novel potential treatments for neuronal channelopathies.

Neuropharmacology. 2018 Apr;132:108-117.

Pecoraro-Bisogni F, Lignani G, Contestabile A, Castroflorio E, Pozzi D, Rocchi A, Prestigio C, Orlando M, Valente P, Massacesi M, Benfenati F, Baldelli P.

REST-Dependent Presynaptic Homeostasis Induced by Chronic Neuronal Hyperactivity.

Mol Neurobiol. 2018 Jun;55(6):4959-4972.

Counsell JR, Karda R, Diaz JA, Carey L, Wiktorowicz T, Buckley SMK, Ameri S, Ng J, Baruteau J, Almeida F, de Silva R, Simone R, Lugarà E, Lignani G, Lindemann D, Rethwilm A, Rahim AA, Waddington SN, Howe SJ.

Foamy Virus Vectors Transduce Visceral Organs and Hippocampal Structures following In Vivo Delivery to Neonatal Mice

Mol Ther Nucleic Acids. 2018 Sep 7;12:626-634.


Morris G, Leite M, Kullmann DM, Pavlov I, Schorge S, Lignani G.

Activity Clamp Provides Insights into Paradoxical Effects of the Anti-Seizure Drug Carbamazepine.

J Neurosci. 2017 May 31;37(22):5484-5495.

Liavas A, Lignani G, Schorge S.

Conservation of alternative splicing in sodium channels reveals evolutionary focus on release from inactivation and structural insights into gating.

J Physiol. 2017 Aug 15;595(16):5671-5685.


Valente P, Lignani G, Medrihan L, Bosco F, Contestabile A, Lippiello P, Ferrea E, Schachner M, Benfenati F, Giovedì S, Baldelli P.

Cell adhesion molecule L1 contributes to neuronal excitability regulating the function of voltage-gated Na+ channels.

J Cell Sci. 2016 May 1;129(9):1878-91.


Caiazzo M, Giannelli S, Valente P, Lignani G, Carissimo A, Sessa A, Colasante G, Bartolomeo R, Massimino L, Ferroni S, Settembre C, Benfenati F, Broccoli V.

Direct conversion of fibroblasts into functional astrocytes by defined transcription factors.

Stem Cell Reports. 2015 Jan 13;4(1):25-36.

Espinoza S, Lignani G, Caffino L, Maggi S, Sukhanov I, Leo D, Mus L, Emanuele M, Ronzitti G, Harmeier A, Medrihan L, Sotnikova TD, Chieregatti E, Hoener MC, Benfenati F, Tucci V, Fumagalli F, Gainetdinov RR.

TAAR1 Modulates Cortical Glutamate NMDA Receptor Function.

Neuropsychopharmacology. 2015 Aug;40(9):2217-27.

Colasante G, Lignani G, Rubio A, Medrihan L, Yekhlef L, Sessa A, Massimino L, Giannelli SG, Sacchetti S, Caiazzo M, Leo D, Alexopoulou D, Dell'Anno MT, Ciabatti E, Orlando M, Studer M, Dahl A, Gainetdinov RR, Taverna S, Benfenati F, Broccoli V.

Rapid Conversion of Fibroblasts into Functional Forebrain GABAergic Interneurons by Direct Genetic Reprogramming.

Cell Stem Cell. 2015 Dec 3;17(6):719-734.


González JC, Lignani G, Maroto M, Baldelli P, Hernández-Guijo JM.

Presynaptic muscarinic receptors reduce synaptic depression and facilitate its recovery at hippocampal GABAergic synapses.

Cereb Cortex. 2014 Jul;24(7):1818-31.

Pozzi D*, Lignani G*, Ferrea E, Contestabile A, Paonessa F, D'Alessandro R, Lippiello P, Boido D, Fassio A, Meldolesi J, Valtorta F, Benfenati F, Baldelli P.

REST/NRSF-mediated intrinsic homeostasis protects neuronal networks from hyperexcitability.

EMBO J. 2013 Nov 13;32(22):2994-3007.

Verstegen AM, Tagliatti E, Lignani G, Marte A, Stolero T, Atias M, Corradi A, Valtorta F, Gitler D, Onofri F, Fassio A, Benfenati F.

Phosphorylation of synapsin I by cyclin-dependent kinase-5 sets the ratio between the resting and recycling pools of synaptic vesicles at hippocampal synapses.

J Neurosci. 2014 May 21;34(21):7266-80.

Orlando M*, Lignani G*, Maragliano L, Fassio A, Onofri F, Baldelli P, Giovedí S, Benfenati F.

Functional role of ATP binding to synapsin I in synaptic vesicle trafficking and release dynamics.

J Neurosci. 2014 Oct 29;34(44):14752-68.


Lignani G, Raimondi A, Ferrea E, Rocchi A, Paonessa F, Cesca F, Orlando M, Tkatch T, Valtorta F, Cossette P, Baldelli P, Benfenati F.

Epileptogenic Q555X SYN1 mutant triggers imbalances in release dynamics and short-term plasticity.

Hum Mol Genet. 2013 Jun 1;22(11):2186-99.

Medrihan L, Cesca F, Raimondi A, Lignani G, Baldelli P, Benfenati F.

Synapsin II desynchronizes neurotransmitter release at inhibitory synapses by interacting with presynaptic calcium channels.

Nat Commun. 2013;4:1512.

Lignani G, Ferrea E, Difato F, Amarù J, Ferroni E, Lugarà E, Espinoza S, Gainetdinov RR, Baldelli P, Benfenati F.

Long-term optical stimulation of channelrhodopsin-expressing neurons to study network plasticity.

Front Mol Neurosci. 2013 Aug 20;6:22.


Galiani S, Harke B, Vicidomini G, Lignani G, Benfenati F, Diaspro A, Bianchini P.

Strategies to maximize the performance of a STED microscope.

Opt Express. 2012 Mar 26;20(7):7362-74.


Fassio A, Raimondi A, Lignani G, Benfenati F, Baldelli P.

Synapsins: from synapse to network hyperexcitability and epilepsy.

Semin Cell Dev Biol. 2011 Jun;22(4):408-15.

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