©2018 by LignaniLab

Published Work

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Molecular Therapy. In press. September 03, 2019. DOI:https://doi.org/10.1016/j.ymthe.2019.08.018

Nat Commun. 2019 Jul 12;10(1):3094. doi: 10.1038/s41467-019-10910-w.

Frontiers in Molecular Neuroscience. 1 May 2019. doi.org/10.3389/fncel.2019.00220

Sci Adv. 2019 Apr 17;5(4):eaaw1567. doi: 10.1126/sciadv.aaw1567.

Rocchi A, Moretti D, Lignani G, Colombo E, Scholz-Starke J, Baldelli P, Tkatch T, Benfenati F.

Neurite-Enriched MicroRNA-218 Stimulates Translation of the GluA2 Subunit and Increases Excitatory Synaptic Strength

Mol Neurobiol. 2019 Jan 23. doi: 10.1007/s12035-019-1492-7

Colasante G*, Qiu Y*, Di Berardino C, Massimino L, Cornford J, Snowball S, Jones S, Giannelli G, Lieb A, Schorge S, Kullmann DM, Broccoli V, Lignani G.

CRISPRa-mediated Kcna1 upregulation decreases neuronal excitability and suppresses seizures in a rodent model of temporal lobe epilepsy

 BioRxiv 431015. 2018. doi:10.1101/431015 (Under Revision)

Counsell JR, Karda R, Diaz JA, Carey L, Wiktorowicz T, Buckley SMK, Ameri S, Ng J, Baruteau J, Almeida F, de Silva R, Simone R, Lugarà E, Lignani G, Lindemann D, Rethwilm A, Rahim AA, Waddington SN, Howe SJ. 

Foamy Virus Vectors Transduce Visceral Organs and Hippocampal Structures following In Vivo Delivery to Neonatal Mice

Mol Ther Nucleic Acids. 2018 Sep 7;12:626-634. doi: 10.1016/j.omtn.2018.07.006.

Pecoraro-Bisogni F*, Lignani G*^, Contestabile A, Castroflorio E, Pozzi D, Rocchi A, Prestigio C, Orlando M, Valente P, Massacesi M, Benfenati F, Baldelli P. 

REST-Dependent Presynaptic Homeostasis Induced by Chronic Neuronal Hyperactivity

Mol Neurobiol. 2018 Jun;55(6):4959-4972. doi: 10.1007/s12035-017-0698-9.

J Physiol. 2017 Aug 15;595(16):5671-5685. doi: 10.1113/JP274693.

Neuropharmacology. 2018 Apr;132:108-117. doi: 10.1016/j.neuropharm.2017.05.029.

Morris G, Leite M, Kullmann DM, Pavlov I, Schorge S, Lignani G. 

Activity Clamp Provides Insights into Paradoxical Effects of the Anti-Seizure Drug Carbamazepine.

J Neurosci. 2017 May 31;37(22):5484-5495. doi: 10.1523/JNEUROSCI.3697-16.2017.

Valente P, Lignani G, Medrihan L, Bosco F, Contestabile A, Lippiello P, Ferrea E, Schachner M, Benfenati F, Giovedì S, Baldelli P.

Cell adhesion molecule L1 contributes to neuronal excitability regulating the function of voltage-gated Na+ channels.

J Cell Sci. 2016 May 1;129(9):1878-91. doi: 10.1242/jcs.182089.

Colasante G, Lignani G, Rubio A, Medrihan L, Yekhlef L, Sessa A, Massimino L, Giannelli SG, Sacchetti S, Caiazzo M, Leo D, Alexopoulou D, Dell'Anno MT, Ciabatti E, Orlando M, Studer M, Dahl A, Gainetdinov RR, Taverna S, Benfenati F, Broccoli V.

Rapid Conversion of Fibroblasts into Functional Forebrain GABAergic Interneurons by Direct Genetic Reprogramming.

Cell Stem Cell. 2015 Dec 3;17(6):719-734. doi: 10.1016/j.stem.2015.09.002.

Espinoza S, Lignani G, Caffino L, Maggi S, Sukhanov I, Leo D, Mus L, Emanuele M, Ronzitti G, Harmeier A, Medrihan L, Sotnikova TD, Chieregatti E, Hoener MC, Benfenati F, Tucci V, Fumagalli F, Gainetdinov RR.

TAAR1 Modulates Cortical Glutamate NMDA Receptor Function.

Neuropsychopharmacology. 2015 Aug;40(9):2217-27. doi: 10.1038/npp.2015.65.

Caiazzo M, Giannelli S, Valente P, Lignani G, Carissimo A, Sessa A, Colasante G, Bartolomeo R, Massimino L, Ferroni S, Settembre C, Benfenati F, Broccoli V.

Direct conversion of fibroblasts into functional astrocytes by defined transcription factors.

Stem Cell Reports. 2015 Jan 13;4(1):25-36. doi: 10.1016/j.stemcr.2014.12.002.

Orlando M*, Lignani G*, Maragliano L, Fassio A, Onofri F, Baldelli P, Giovedí S, Benfenati F.

Functional role of ATP binding to synapsin I in synaptic vesicle trafficking and release dynamics.

J Neurosci. 2014 Oct 29;34(44):14752-68. doi: 10.1523/JNEUROSCI.1093-14.2014.

Verstegen AM, Tagliatti E, Lignani G, Marte A, Stolero T, Atias M, Corradi A, Valtorta F, Gitler D, Onofri F, Fassio A, Benfenati F.

Phosphorylation of synapsin I by cyclin-dependent kinase-5 sets the ratio between the resting and recycling pools of synaptic vesicles at hippocampal synapses.

J Neurosci. 2014 May 21;34(21):7266-80. doi: 10.1523/JNEUROSCI.3973-13.2014.

Pozzi D*, Lignani G*, Ferrea E, Contestabile A, Paonessa F, D'Alessandro R, Lippiello P, Boido D, Fassio A, Meldolesi J, Valtorta F, Benfenati F, Baldelli P.

REST/NRSF-mediated intrinsic homeostasis protects neuronal networks from hyperexcitability.

EMBO J. 2013 Nov 13;32(22):2994-3007. doi: 10.1038/emboj.2013.231.

Lignani G, Ferrea E, Difato F, Amarù J, Ferroni E, Lugarà E, Espinoza S, Gainetdinov RR, Baldelli P, Benfenati F.

Long-term optical stimulation of channelrhodopsin-expressing neurons to study network plasticity.

Front Mol Neurosci. 2013 Aug 20;6:22. doi: 10.3389/fnmol.2013.00022

Nat Commun. 2013;4:1512. doi: 10.1038/ncomms2515.

Cereb Cortex. 2014 Jul;24(7):1818-31. doi: 10.1093/cercor/bht032.

Lignani G, Raimondi A, Ferrea E, Rocchi A, Paonessa F, Cesca F, Orlando M, Tkatch T, Valtorta F, Cossette P, Baldelli P, Benfenati F.

Epileptogenic Q555X SYN1 mutant triggers imbalances in release dynamics and short-term plasticity.

Hum Mol Genet. 2013 Jun 1;22(11):2186-99. doi: 10.1093/hmg/ddt071

Galiani S, Harke B, Vicidomini G, Lignani G, Benfenati F, Diaspro A, Bianchini P.

Strategies to maximize the performance of a STED microscope.

Opt Express. 2012 Mar 26;20(7):7362-74. doi: 10.1364/OE.20.007362.

Fassio A, Raimondi A, Lignani G, Benfenati F, Baldelli P.

Synapsins: from synapse to network hyperexcitability and epilepsy.

Semin Cell Dev Biol. 2011 Jun;22(4):408-15. doi: 10.1016/j.semcdb.2011.07.005. Review