Published Work
Front Mol Neurosci. 2022 Feb 16;15:839366. doi: 10.3389/fnmol.2022.839366. eCollection 2022.
Nat Commun. 2022 Jan 10;13(1):161. doi: 10.1038/s41467-021-27837-w
Prestigio C, Ferrante D, Marte A, Romei A, Lignani G, Onofri F, Valente P, Benfenati F, Baldelli P.
REST/NRSF drives homeostatic plasticity of inhibitory synapses in a target-dependent fashion.
Elife. 2021 Dec 2;10:e69058. doi: 10.7554/eLife.69058.
Neurotherapeutics. 2021 Jul 7. doi: 10.1007/s13311-021-01081-y
Science Translational Medicine. 2021 May 19. doi: 10.1126/scitranslmed.aaw1564
Brain 2021 Apr 12;144(3):702-705. doi: 10.1093/brain/awab051
Carpenter JC, Männikkö R, Heffner C, Heneine J, Sampedro-Castañeda M, Lignani G, Schorge S.
Progressive myoclonus epilepsy KCNC1 variant causes a developmental dendritopathy
Epilepsia. 2021 May;62(5):1256-1267. doi: 10.1111/epi.16867. Epub 2021 Mar 18.
Brain. 2021 Mar 17:awab123. doi: 10.1093/brain/awab123
Front Neurosci. 2021 Feb 18;15:632522. doi: 10.3389/fnins.2021.632522. eCollection 2021.
Epilepsia. 2020 Oct 26. doi: 10.1111/epi.16736.
Turner T, Zourray C, Schorge S and Lignani G
Recent advances in gene therapy for neurodevelopmental disorders with epilepsy
Lignani G., Baldelli P, Marra V
Colasante G*, Qiu Y*, Massimino L, Di Berardino C, Cornford JH, Snowball A, Weston M, Jones SP, Giannelli S, Lieb A, Schorge S, Kullmann DM, Broccoli V, Lignani G.
In vivo CRISPRa decreases seizures and rescues cognitive deficits in a rodent model of epilepsy
Brain. 2020 Mar 1;143(3):891-905. doi: 10.1093/brain/awaa045.
Jacy L. Wagon. Promoting CRISPRa for Targeted Treatment of Epilepsy
Epilepsy Currents July 2020; *** Commentary ***
dCas9-based Scn1a gene activation restores inhibitory interneuron excitability and attenuates seizures in Dravet syndrome mice
Molecular Therapy. 2020 Jan 8; 28(1): 235–253.. doi:https://doi.org/10.1016/j.ymthe.2019.08.018
Ethan M. Goldberg. Gene Therapy in Models of Severe Epilepsy due to Sodium Channelopathy
Epilepsy Currents June 2020
Salpietro V, Dixon CL, Guo H, Bello OD et al.
AMPA receptor GluA2 subunit defects are a cause of neurodevelopmental disorders.
Nat Commun. 2019 Jul 12;10(1):3094. doi: 10.1038/s41467-019-10910-w.
Frontiers in Molecular Neuroscience. 1 May 2019. doi.org/10.3389/fncel.2019.00220
Weston M, Kaserer T, Wu A, Mouravlev A, Carpenter JC, Snowball A, Knauss S, von Schimmelmann M, During MJ, Lignani G, Schorge S, Young D, Kullmann DM, Lieb A
Sci Adv. 2019 Apr 17;5(4):eaaw1567. doi: 10.1126/sciadv.aaw1567.
Rocchi A, Moretti D, Lignani G, Colombo E, Scholz-Starke J, Baldelli P, Tkatch T, Benfenati F.
Mol Neurobiol. 2019 Jan 23. doi: 10.1007/s12035-019-1492-7
Colasante G*, Qiu Y*, Di Berardino C, Massimino L, Cornford J, Snowball S, Jones S, Giannelli G, Lieb A, Schorge S, Kullmann DM, Broccoli V, Lignani G.
CRISPRa-mediated Kcna1 upregulation decreases neuronal excitability and suppresses seizures in a rodent model of temporal lobe epilepsy
BioRxiv 431015. 2018. doi:10.1101/431015 (Under Revision)
Counsell JR, Karda R, Diaz JA, Carey L, Wiktorowicz T, Buckley SMK, Ameri S, Ng J, Baruteau J, Almeida F, de Silva R, Simone R, Lugarà E, Lignani G, Lindemann D, Rethwilm A, Rahim AA, Waddington SN, Howe SJ.
Mol Ther Nucleic Acids. 2018 Sep 7;12:626-634. doi: 10.1016/j.omtn.2018.07.006.
Pecoraro-Bisogni F*, Lignani G*^, Contestabile A, Castroflorio E, Pozzi D, Rocchi A, Prestigio C, Orlando M, Valente P, Massacesi M, Benfenati F, Baldelli P.
REST-Dependent Presynaptic Homeostasis Induced by Chronic Neuronal Hyperactivity
Mol Neurobiol. 2018 Jun;55(6):4959-4972. doi: 10.1007/s12035-017-0698-9.
Liavas A, Lignani G, Schorge S.
J Physiol. 2017 Aug 15;595(16):5671-5685. doi: 10.1113/JP274693.
Wykes RC, Lignani G.
Gene therapy and editing: Novel potential treatments for neuronal channelopathies
Neuropharmacology. 2018 Apr;132:108-117. doi: 10.1016/j.neuropharm.2017.05.029.
Morris G, Leite M, Kullmann DM, Pavlov I, Schorge S, Lignani G.
Activity Clamp Provides Insights into Paradoxical Effects of the Anti-Seizure Drug Carbamazepine.
J Neurosci. 2017 May 31;37(22):5484-5495. doi: 10.1523/JNEUROSCI.3697-16.2017.
Valente P, Lignani G, Medrihan L, Bosco F, Contestabile A, Lippiello P, Ferrea E, Schachner M, Benfenati F, Giovedì S, Baldelli P.
J Cell Sci. 2016 May 1;129(9):1878-91. doi: 10.1242/jcs.182089.
Colasante G, Lignani G, Rubio A, Medrihan L, Yekhlef L, Sessa A, Massimino L, Giannelli SG, Sacchetti S, Caiazzo M, Leo D, Alexopoulou D, Dell'Anno MT, Ciabatti E, Orlando M, Studer M, Dahl A, Gainetdinov RR, Taverna S, Benfenati F, Broccoli V.
Cell Stem Cell. 2015 Dec 3;17(6):719-734. doi: 10.1016/j.stem.2015.09.002.
Espinoza S, Lignani G, Caffino L, Maggi S, Sukhanov I, Leo D, Mus L, Emanuele M, Ronzitti G, Harmeier A, Medrihan L, Sotnikova TD, Chieregatti E, Hoener MC, Benfenati F, Tucci V, Fumagalli F, Gainetdinov RR.
Neuropsychopharmacology. 2015 Aug;40(9):2217-27. doi: 10.1038/npp.2015.65.
Caiazzo M, Giannelli S, Valente P, Lignani G, Carissimo A, Sessa A, Colasante G, Bartolomeo R, Massimino L, Ferroni S, Settembre C, Benfenati F, Broccoli V.
Direct conversion of fibroblasts into functional astrocytes by defined transcription factors.
Stem Cell Reports. 2015 Jan 13;4(1):25-36. doi: 10.1016/j.stemcr.2014.12.002.
Orlando M*, Lignani G*, Maragliano L, Fassio A, Onofri F, Baldelli P, Giovedí S, Benfenati F.
Functional role of ATP binding to synapsin I in synaptic vesicle trafficking and release dynamics.
J Neurosci. 2014 Oct 29;34(44):14752-68. doi: 10.1523/JNEUROSCI.1093-14.2014.
Verstegen AM, Tagliatti E, Lignani G, Marte A, Stolero T, Atias M, Corradi A, Valtorta F, Gitler D, Onofri F, Fassio A, Benfenati F.
J Neurosci. 2014 May 21;34(21):7266-80. doi: 10.1523/JNEUROSCI.3973-13.2014.
Pozzi D*, Lignani G*, Ferrea E, Contestabile A, Paonessa F, D'Alessandro R, Lippiello P, Boido D, Fassio A, Meldolesi J, Valtorta F, Benfenati F, Baldelli P.
REST/NRSF-mediated intrinsic homeostasis protects neuronal networks from hyperexcitability.
EMBO J. 2013 Nov 13;32(22):2994-3007. doi: 10.1038/emboj.2013.231.
Lignani G, Ferrea E, Difato F, Amarù J, Ferroni E, Lugarà E, Espinoza S, Gainetdinov RR, Baldelli P, Benfenati F.
Long-term optical stimulation of channelrhodopsin-expressing neurons to study network plasticity.
Front Mol Neurosci. 2013 Aug 20;6:22. doi: 10.3389/fnmol.2013.00022
Medrihan L, Cesca F, Raimondi A, Lignani G, Baldelli P, Benfenati F.
Nat Commun. 2013;4:1512. doi: 10.1038/ncomms2515.
González JC, Lignani G, Maroto M, Baldelli P, Hernández-Guijo JM.
Cereb Cortex. 2014 Jul;24(7):1818-31. doi: 10.1093/cercor/bht032.
Lignani G, Raimondi A, Ferrea E, Rocchi A, Paonessa F, Cesca F, Orlando M, Tkatch T, Valtorta F, Cossette P, Baldelli P, Benfenati F.
Epileptogenic Q555X SYN1 mutant triggers imbalances in release dynamics and short-term plasticity.
Hum Mol Genet. 2013 Jun 1;22(11):2186-99. doi: 10.1093/hmg/ddt071
Galiani S, Harke B, Vicidomini G, Lignani G, Benfenati F, Diaspro A, Bianchini P.
Strategies to maximize the performance of a STED microscope.
Opt Express. 2012 Mar 26;20(7):7362-74. doi: 10.1364/OE.20.007362.
Fassio A, Raimondi A, Lignani G, Benfenati F, Baldelli P.
Synapsins: from synapse to network hyperexcitability and epilepsy.
Semin Cell Dev Biol. 2011 Jun;22(4):408-15. doi: 10.1016/j.semcdb.2011.07.005. Review
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