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Department of Clinical and Experimental Epilepsy

Queen Square Institute of Neurology

University College London


The main focus of my lab is finding novel gene therapy approaches for intractable neurological diseases, with rapid potential for translation. We start by investigating the pathophysiological mechanisms of disease and then use novel insights to develop and improve therapeutic tools to cure them. The Lignani Lab is located at the Queen Square Institute of Neurology, part of the University College London (UCL). 


The UCL Queen Square Institute of Neurology (ION) in Queen Square was established in 1950, merged with UCL in 1997, and is a key component of the Faculty of Brain Sciences (FBS), School of Life and Medical Sciences (SLMS), at UCL. The Institute has eight academic research Departments (https://www.ucl.ac.uk/ion/research/research-departments), which encompass clinical and basic research within each theme. In parallel, there are currently six Divisions representing clinical professional affiliations. 

The mission is to translate neuroscience discovery research into treatments for patients with neurological diseases. In addition, a number of important research centres are based at the ION, affiliated with one of our academic research departments: https://www.ucl.ac.uk/ion/research/research-centres

The Department of Clinical and Experimental Epilepsy (website) at the UCL Queen Square Institute of Neurology has been ranked No. 1 in the world for epilepsy research (http://www.expertscape.com/ex/epilepsy/i/university_college_london).   

Experimental research spans across fundamental mechanisms of vesicle fusion and synaptic transmission, ion channel biology, experimental models of epilepsy, the function of neural circuits, neurological diseases modelled in rodents and flies and gene therapy for epilepsy.

There are 9 Principal Investigators in the experimental part: DM Kullmann, MC Walker, DA Rusakov, J Jepson, K Volynski, JE Rothman, G Lignani, V Magloire and R Wykes.